Each ml contains:
250mg of Testosterone Enanthate.
What is it used for?
Testosterone replacement therapy in men with low or no production of natural testosterone (hypogonadism).
How is it given?
Testosterone enantate injection is known as a depot injection. It is injected into a muscle, where it forms a reservoir of medicine that is gradually converted into testosterone over time. For low testosterone levels the injection is initially given once every two to three weeks, and then every three to six weeks for maintenance treatment.The exact frequency will depend on your individual testosterone level.
Storage:
- The syringes and ampoules should be protected from light and stored below 30°C.
- Keep out of reach of children.
Shelf life:
5 years
Pharmocological action
Testosterone enantate injection contains the active ingredient testosterone enantate, which is an ester of the naturally occurring male hormone testosterone.
Testosterone is known as an androgen. It is produced by the testicles and is the main hormone essential for normal growth and development of the male sex organs and male sexual characteristics.
The natural production of testosterone is controlled by another set of hormones called gonadotrophins, which are released from the pituitary gland in the brain.
During adult life, testosterone is essential for the production of sperm, the maintenance of sex drive, erectile potency, and the functioning of the prostate gland and other reproductive structures. It also has functions in the skin, muscles, skeleton, kidney, liver, bone marrow and central nervous system.
Low levels of testosterone can cause decreased sex drive, impotence, infertility due to decreased sperm production, decreased mental and physical activity, fatigue and weakening of bones (osteoporosis). Testosterone is given as replacement therapy when natural testosterone levels fall too low, causing problems such as those above.
Natural testosterone levels fall slowly with age and fall rapidly following surgical removal of the testicles (for example in the treatment of testicular cancer).They may also fall due to decreased functioning of the testicles (hypogonadism or eunuchoidism) caused by testicular disease, or by decreased gonadotrophin production by the pituitary gland, as a result of pituitary disease.
Testosterone replacement allows natural testosterone levels to return to normal, thus relieving the symptoms of the deficiency.
Warning!
You will need to have blood tests to measure your blood level of testosterone before starting and regularly throughout treatment with this medicine.
Tell your doctor if you experience symptoms such as frequent or persistent erections, irritability, nervousness or weight gain after starting treatment with this medicine, as these suggest your testosterone levels are too high and your dose may need adjusting.
You will also need to have regular blood tests to monitor your red blood cells, liver function and prostate specific antigen (PSA) levels.
Testosterone can increase the growth of prostate cancers and benign enlargement of the prostate. Your doctor will perform various examinations to make sure you don’t have prostate cancer before you start treatment with this medicine. Your doctor will need to perform a digital rectal exam to checkyour prostate gland at least once a year while you are receiving testosterone replacement (more frequently than this if you are elderly or have risk factors for prostate cancer).
Use with caution in
Boys who have not yet reached puberty.
Elderly people.
People with a history of kidney or liver disease.
People with a history of heart disease, eg heart attack or heart failure.
People with a history of high blood pressure (hypertension).
Epilepsy.
Diabetes.
People with a history of migraines.
People with sleep apnoea (when breathing temporarily stops during sleep).
People with cancer that has spread from its original site to the bones (skeletal metastases).
Not to be used in
Women.
Prostate cancer.
Breast cancer.
People with a history of primary liver cancer.
People with a kidney disorder called nephrosis or nephrotic syndrome.
People with a high level of calcium in their blood (hypercalcaemia).
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Side effects
Medicines and their possible side effects can affect individual people in different ways.The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Reaction at the injection site.
Prostate problems, such as growth of the prostate gland, increased PSA levels and prostate cancer (see warning section above).
Headache.
Feeling sickand vomiting.
Mood changes.
Depression.
Nervousness, anxiety or irritability.
Change in sexdrive.
Breast pain, enlargement of the breasts.
Persistent painful erection of the penis (priapism).Tell your doctor straight away if you experience this.
Decreased sperm count.
Swelling caused byfluid retention (oedema).
Increased blood pressure (hypertension).
Increased levels of red blood cells and haemoglobin in the blood (polycythaemia).
Weight gain.
Pain in the muscle or joints.
Male-pattern hair loss.
Acne.
Itching.
Raised cholesterol levels.
Jaundice.
Livertumours.
Premature sexual development if used in boys who haven’t reached puberty.
Premature closure of the ends of bones, causing stunted growth if used in boys who haven’t reached puberty.
The side effects listed above may not include all of the side effects reported by the medicine’s manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
Identification
Aclearoily solution.
Storage instructions
The syringes and ampoules should be protected from light and stored below 30°C.
Keep out of reach of children.
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