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Mesterolone is a synthetic, orally effective androgen which does not have any anabolic characteristics. In the school of medicine they use Mesterolone to ease or cure disturbances caused by a deficiency of male sex hormones. Many athletes believe that using Mesterolone at the end of a steroid cycle will increase testosterone production. This, however, is not a good idea since Mesterolone has no effect on the body’s own testosterone production but, as mentioned in the beginning, only reduces or completely eliminates the dysfunctions caused by the testosterone deficiency.

Uses in Bodybuilding

Most, however, do not know the main use of Mesterolone in bodybuilding. You should be aware that Mesterolone is also an estrogen antagonist which prevents the aromatization of steroids. Unlike the anti-estrogen Tamoxifen which only blocks the estrogen receptors (see Tamoxifen) Mesterolone already prevents the aromatizing of steroids. Gynecomastia and increased water retention are successfully blocked. Mesterolone strongly suppresses the forming of estrogens and no rebound effect occurs after discontinuation as case with Tamoxifen for example, where an aromatization of the steroids is not prevented. One can say that Mesterolone cures the problem of aromatization at its root while Tamoxifen simply cures the symptoms. For this reason male athletes should prefer Mesterolone to Tamoxifen.

Mesterolone causes an increase in androgen levels so the athlete obtains more muscle hardness. This, in particular, is noted positively during the preparation for a competition when used in combination with a diet. Female athletes who naturally have a higher estrogen level often supplement their steroid intake with Mesterolone resulting in an increased muscle hardness.


In the past it was common for bodybuilders to take a daily dose of one 25 mg tablet over several weeks, sometimes even months, in order to appear hard all year round. This was especially important for athletes making appearances at guest performances, seminars and photo sessions. Today athletes take Clenbuterol

over the entire year because possible virilization symptoms cannot occur which is not yet the case with Mesterolone.

Since Mesterolone is very effective, male athletes usually need only 50mg/day which means that the athlete usually takes one 25mg tablet in the morning and another 25mg tablet in the evening. In some cases one 25 mg tablet per day is sufficient. When combining Mesterolone with Tamoxifen (50 mg Mesterolone/day and 20 mg Tamoxifen/day) this will lead to an almost complete suppression of estrogen.

Side Effects

Side effects in men are low at a dosage of 2-3 tablets/day. Athletes use Mesterolone with comparatively low risk in combination with other steroids. Even over several weeks. Since the liver tolerates Mesterolone well no dysfunction occurs in the given dosages. Athletes who believe ”more is better” could experience a paradoxical effect. The German manufacturer, Jenapharm, writes about its compound Vistimon in the package insert:

”In high-dosage treatments an occasional retention of electrolytes and water, and edemas (accumulation of excessive water in tissues) can occur.”

Those taking less than 2-4 tablets daily do not have to worry about this. The most common side effect of Mesterolone, or in this case, secondary symptom, is in part a distinct sexual over-stimulation and in some cases continuous penis erection. This condition can be painful and lead to possible damage. Lowering the dose or discontinuing the compound are the only sensible solutions.

Female athletes should use Mesterolone with caution. You cannot exclude the possibility of androgenic side effects. Women who want to give Mesterolone a try should not take more than one 25 mg tablet per day. Higher dosages and periods of intake of more than four weeks considerably increase the risk of virilization symptoms. Female athletes who have no difficulties with Mesterolone obtain good results with 25 mg Mesterolone/day and 20 mg Tamoxifen/day. In combination with a diet, report an accelerated fat breakdown and continuously harder muscles.


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